Comparison Of Clinical And Histological Parameters In Biliary Atresia Patients With And Without Ductal Plate Malformation

Background And Aim: Biliary atresia (BA) can be associated with ductal plate malformation (DPM) like changes in as high 40% of patients. It is variable prognosis, most the studies suggesting poor overall outcome. Aim isto study clinical and histological parameters biliary patients without DPM. Methods: Medical records diagnosed from January 2021 to September 2022 were analyzed. Histology every patient was reviewed by expert pathologist classifying them into BA Results: A total 84 included median age 3 months. 66.7% males. 35 cases (41.66%) had DPM changes. Age at onset jaundice physical examination findings similar among two groups. Overall, 13(15.5%) ascites presentation. Biochemical synthetic liver functions no different between In histopathology, group showed higher degrees ductular reaction grades fibrosis comparison (p=0.003). 41 (48.8%) underwent portoenterostomy survival 12.65%. Among who PE, short term (<3 years) rate 25%. Survival or When key features analysed, we observed advanced (Grade 4) a degree which statistically significant (p=0.002). None mild-moderate (0.003). Patients PE lower (p=0.019) portal inflammation(p=0.007). Conclusions: Presence not uncommon differences outcome our cohort. The exuberant histopathology feature induces DPM-like arrays atresia.